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Adverse Effect: Any undesirable, unfavorable, unintended, or dangerous reaction. Tylenol (Acetaminophen) - Dark Urine - Yellowing of the skin or eyes Allergic Reaction - Difficulty breathing - ... Swelling (Face, Lips, Tongue or Throat) Call 911 Side Effect: An effect that is secondary, or additional, to the on intended. Tylenol (Acetaminophen) - Upset stomach - Nausea - Loss of appetite - Itching Call HCP Adverse Effects vs Side Effects Substance P Prostaglandis Bradykinis Histamine Pain-mediating chemicals 1. The pain impulse travels along the sensory nerve from the origin of pain in the periphery, to the dorsal horn of the spinal cord. 2. IF the dorsal horn conducts the pain sensation up the spinal cord to the cerebral cortex and thalamus, it's then interpreted in relation to the location and type of pain. 3. Once the brain interprets the pain, the body releases body's natural pain killers; serotonin, enkephalins, and endorphins in response to pain pain. Sensory: Pain There are gates in the spinal cord that open or close in relation to the conduction of pain up the spinal cord to the brain. According to "Gate Theory" Transcutaneous Electrical Nerve Stimulation Unit TENS Unit stands for... S.E.E. Serotinon Enkephalins Endorphins These bind with opioid receptors and inhibit the conduction of pain impulses. Releif of a decrease of pain is the outcome. Body's natural pain killers 11/27/2019 Print ATI Pharmacology: Module: Pain and Inflammation flashcards | Easy Notecards https://www.easynotecards.com/print_list/95534 2/34 7. 8. 9. 10. 1. MU 2. KAPPA 3. DELTA Three types of Opioid Receptors Analgesia, euphoria, sedation Respiratory depression Physical dependence > Stimulated by opioid drugs. > They cause analgesia or relief of pain whenever receptors are stimulated. > Stimulation causes respiratory depression, euphoria, sedation, and physical dependence. MU opioid receptor Analgesia, sedation Psychic Effects > Stimulated by opioid drugs. > They cause analgesia, sedation, and psychotomimetic effects whenever receptors are stimulated KAPPA opioid receptor No pharmacology-related effects 11/27/2019 Print ATI Pharmacology: Module: Pain and Inflammation flashcards | Easy Notecards https://www.easynotecards.com/print_list/95534 3/34 11. 12. 13. 14. 15. 16. 17. DELTA opioid receptor respiratory depression euphoria sedation physical dependence. What are the effects that are primary concerns when administering opiod analgesics? Effects that mimic psychosis such as hallucinations and delusion. What is psychotomimetic effects? > Occurs secondary to injury Pain Inflammation Fever Edema > Chemical mediators Bradykinins Histamine Prostaglandins Inflammatory Response Bradykinins Histamine Prostaglandins What are the mediating chemicals released in response to cellular damage? Pain Inflammation Fever Edema What are the local reaction to mediating chemicals? Substance P Prostaglandins Bradykinins Histamine Substances that increase pain transmission and cause an inflammatory response. Serotonin Endorphins Enkephalins Substances that decrease paint transmission and produce analgesia [Show More]

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