Pharm midterm study guide Review of Basic Principles of Pharmacology

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1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to prescribing because: Distribution of drugs to target tissue may be affected. 2. Drugs that ... have a significant first-pass effect: Are rapidly metabolized by the liver and may have little if any desired action 3.The route of excretion of a volatile drug will likely be the: Lungs 4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage reservoir Increase the length of time a drug is available and active 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s: Biological half-life 6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the prescription. This is considered a loading dose. A loading dose: Rapidly achieves drug levels in the therapeutic range 7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the: Onset of action 8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done: To determine if a drug is in the therapeutic range 9. A laboratory result indicates that the peak level for a drug is above the minimum toxic concentration. This means that the: Concentration will produce an adverse response 10. Drugs that are receptor agonists may demonstrate what property? Desensitization or downregulation with continuous use 11. Drugs that are receptor antagonists, such as beta blockers, may cause: An exaggerated response if abruptly discontinued 12. Factors that affect gastric drug absorption include: Lipid solubility of the drug 13. Drugs administered via IV: Begin distribution into the body immediately 14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is: Greater than the sum of the effects of each drug individually 15. Which of the following statements about bioavailability is true? Bioavailability issues are especially important for drugs with narrow therapeutic ranges or sustained-release mechanisms. 16.Which of the following statements about the major distribution barriers (blood-brain or fetalplacental) is true? The blood-brain barrier slows the entry of many drugs into and from brain cells. 17.Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose of both of these types of reactions is to: Change drug molecules to a form that an excretory organ can excrete 18. Once they have been metabolized by the liver, the metabolites may be: More active than the parent drug Less active than the parent drug Totally “deactivated” so they are excreted without any effect 19. All drugs continue to act in the body until they are changed or excreted. The ability of the body to excrete drugs via the renal system would be increased by: Unbinding a nonvolatile drug from plasma proteins 20. Steady state is: When the amount of drug in the body remains constant 21. Two different pain medications are given together for pain relief. The drug—drug interaction Additive 22.Actions taken to reduce drug—drug interaction problems include all of the following EXCEPT: Prescribing a third drug to counteract the adverse reaction of the combination 23. Phase I oxidative-reductive processes of drug metabolism require certain nutritional elements. Which of the following would reduce or inhibit this process? Neither Protein malnutrition OR Iron-deficiency anemia [Show More]

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