Biology > LECTURE NOTES > Lecture Materials > University of Louisville BIO 240 Ch 11 Cell Signaling Notes (All)
University of Louisville BIO 240 Ch 11 Cell Signaling Notes Lecture Notes Local and Long Distance Signaling o Communication between cells using gap junctions (animal cells) or plasmodesmata ... (plant cells), as well as cell to cell recognition The Three Stages of Cell Signaling 1. Reception 1. Transduction 2. Response Reception - A signaling molecule binds to a receptor protein, causing it to change shape o The binding between a signal molecule (ligand) and receptor is highly specific o A shape change in a receptor is often the initial transduction of the signal o Most signal receptors are plasma membrane proteins Receptors in Plasma Membrane (kinase - enzymes that phosphorylate) Transduction: Cascades of molecular interactions relay signals from receptors to target molecules in the cell o Signal Transduction usually involves multiple steps Protein Phosphorylation and dephosphorylation o In many pathways, the signal is transmitted by a cascade of protein phosphorylation Apoptosis integrates multiple cell-signaling pathways o Apoptosis is programmed or controlled cell suicide AP Bio Notes Cell Signaling Synthesis, release, transport of signaling molecules o Neurotransmitters, hormones, etc. o Ligand binds to a specific receptor Reception of Information by target cells Signal Transduction o Receptor converts extracellular signal into intracellular signal o Causes change in cell Response by the cell Signaling Molecules Local Regulators - work locally Neurotransmitters - within the nervous system (synaptic cleft) Hormones - move greater distances (secreted in glands) Local Regulators o Paracrine Regulation - Diffuse through interstitial fluid, act on nearby cells Examples - histamine, growth factors, prostaglandins, nitric oxide Hormones o Chemical Messengers; in plants and animals o Secreted by endocrine glands; in animals o Transported by blood; to target cells Receptors Specific Shape [Show More]
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