Testing Principles and Diagnostic Strategies, Principles of Endocrinology, Principles of Immunoassays; This set will test you on the testing principles and diagnostic strategies for thyroid hormone, cortisol, and PTH/Sex Steroids. It will also test the general principles of endocrinology and immunoassays. 20 QnA Plus Explanation.

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1. A 10-year-old boy presents to the physician with random episodes of sweating, racing heartbeat, intractable headaches, and an immense amount of energy. He rarely sleeps. His mom calls him the energ... izer bunny. 1. Insulinoma 2. Pheochromocytoma 3. Neuroblastoma 4. Incidentaloma 2. What condition is caused by an autonomous cortisol-secreting tumor in the anterior pituitary gland? 1. Addison Disease 2. Conn Syndrome 3. Cushing Disease 4. Cushing Syndrome 3. What hormone activates nuclear receptors to amplify gene transcription 1. Polypeptide 2. Lipid 3. Amino Acid derived 4. Steroid 4. A serum sample comes in and has decreased TSH and the presence of anti-TPO antibodies. What would you expect the T4 to be? 1. Elevated 2. Normal 3. Decreased 4. Non existant 5. What does the LH spike signify? 1. Follicular development 2. Menstruation 3. Ovulation 4. Menopause 6. What hormone is secreted by the hypothalamus to regulate thyroxine? 1. Thyrotropin releasing hormone 2. Triiodothyronine 3. Thyroxine 4. Thyroxine Stimulating Hormone 7. Where does deiodination of T4 take place? 1. Interstitium 2. follicular cell 3. parathyroid cell 4. colloid 8. How do you resolve antibody interference? 1. Dilution 2. Mix the sample by inversion 3. light exposure 4. Cool the sample 9. What type of hormone is Parathyroid hormone? 1. Polypeptide 2. Amino Acid-derived 3. Lipid 4. Steroid 10. What is the significance of a protein-bound hormone? 1. It is the physiologically active portion of hormone because it is bound to the protein 2. It is the physiologically active portion of hormone because it is less likely to be excreted in urine 3. It is the physiologically inactive portion of hormone because it is bound to the protein 4. It is the physiologically inactive portion of hormone because it is more likely to be excreted in urine 11. What is the hormone that we test to identify menopause? 1. Estrogen 2. Progesterone 3. LH 4. FSH 12. What is the stimulus for PTH secretion in the parathyroid cells? 1. High thyroid hormone levels 2. Low Calcium levels 3. Low thyroid hormone levels 4. High Calcium levels 13. What is a common mechanism behind interference in antibody testing? 1. The signal detaches from the labeled antibody 2. Antibodies bind junk in the sample 3. The primary antibody doesn't bind to the secondary antibody 4. Antibodies do not bind with great affinity or avidity to the antigen 14. What does a direct competitive ELISA test signify? 1. The antibody binds to a labeled antibody, but not to the antigen of interest 2. The antibody binds the antigen of interest and another labeled antigen 3. The antibody binds another antibody of the antigen of interest 4. The antibody destroys the antigen 15. What hormones regulate Cortisol production? 1. CAH 2. CRH 3. ACTH 4. CMS 16. List the proper order of a direct ELISA (1) Primary antibodies bind the substrate, (2) Secondary antibodies bind to the complex, (3) The signal is detected, (4) Wash step 1. 2,1,4,3 2. 1,2,3,4 3. 1,4,2,3 4. 3,4,2,1 17. What laboratory results would you expect with Graves disease? 1. High T3, T4, Low TSH, anti-TPO, and anti-TSHR 2. low T3, T4, TSH and no autoantibodies 3. high T3, T4, TSH and no autoantibodies 4. low T3, T4, high TSH and anti-TPO antibodies 18. What stress hormone is also a steroid? 1. Epinephrine 2. Serotonin 3. Cortisol 4. Norepinephrine 19. A hormone is secreted without stimulation and is no longer able to be properly regulated by the body. What is this called? 1. Diurnal Rhythm 2. Homogeneous 3. Heterogeneous 4. Autonomous 20. What is a confusing and indirect measurement of Thyroid Binding Globulin levels? 1. FT3 2. FT4 3. Reverse T3 Binding test 4. T3 Resin Uptake test [Show More]

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