Gastrointestinal pharmacology gi2012

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Gastrointestinal Pharmacology Pathophysiology of Peptic Ulcers • produced by an imbalance between luminal aggresors (H. pylori, NSAIDS, acid, pepsin, bile) • and mucosal d... efense (prostaglandins, mucus, bicarbonate, blood flow) Pathophysiology of Peptic Ulcers LUMINAL AGGRESSORS Acid Pepsin (gastric enzyme) Alcohol Bile NSAIDs H. pylori MUCOSAL DEFENSE Bicarbonate neutralizes acid Mucus protects lining Blood flow can transport acid away Prostaglandins stimulates all above blood flow is H+ a last line of defense as it allows gastric cells to evacuate any H+ molecules that make it through the other lines H+ of defense Peptic Ulcers http://www.gastrolab.net/lc1.htm Causes of Peptic Ulcer Disease DUODENAL ULCER 2% 2% GASTRIC ULCER 3% 13% 5% 80% 25% 70% H.pylori NSAIDs Idiopathic Others Helicobacter pylori • In 1982, two physicians confirmed the link between gastritis and a bacteria found in the stomach • Spiral shaped, microaerophilic, GRAM -ve with unipolar flagella • Fecal/oral or oral/oral transmission • Reservoirs: humans, water supplies ...........................................................................continued.............................................................................................. [Show More]

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