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M5 FINAL COACHING EXAM - Questions and Answers (Complete Solutions)

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M5 FINAL COACHING EXAM - Questions and Answers (Complete Solutions) Identify cosmetics which are regulated as drugs. A. Hair colors, toothpastes B. Skin moisturizers, perfumes, nail polishes C. Sham... poos, lipsticks D. Mouthwashes, antiperspirants, diaper ointments, lip balms Identify the use of Potassium Diformate in veterinary medicine. A. Antiparasitic B. Strong antimicrobial C. Anti-acidic agent D. Sedative Which statements BEST describe the local effects of drugs? I. Local effects are felt in the general area of administration. II. A drug can have both local and systemic effects on the body regardless of the method and route of administration. III. The main route for local effect is topical. IV. Drugs intended for local effect must enter the bloodstream. A. II, III B. II, III, IV C. I, II, III D. I, III Which drugs have a systemic effect? I. Povidone-iodine topical solution II. Fentanyl Patch III. Nicotine Patch IV. Salmeterol Inhalation A. III, IV B. I, III, II, III, IV C. I, II D. II, III, IV How is a powder composed of particles that all pass through a No. 80 sieve classified? A. Coarse powder B. Fine powder C. Very fine powder D. Very coarse powder Analyze which method of preparing powders may be employed both to comminute and mix the ingredients; for comminution purposes, a porcelain or Wedgewood mortar with a rough inner surface is preferred; and for chemicals that may stain the porcelain or Wedgewood surface, a glass mortar is preferred. A. Mechanical mixing B. Sifting C. Trituration D. Tumbling Identify the method of preparing powders that consists of enclosing the powder in a large container, which rotates and mixes the powder ingredients. A. Sifting B. Tumbling C. Trituration D. Mechanical mixing The following are the advantages of granules over powders, EXCEPT A. Better flow property B. Not easily wetted by liquids C. More stable to humidity D. less tendency to cake or harden Analyze and select the basic product formulation for a tablet. A. Active ingredient, diluent, lubricant B. Active ingredient, solvent, emulsifier, lubricant C. Active ingredient, solubilizing agent, binder, disintegrant, filler D. Active ingredient, diluent or filler, binder, disintegrant, lubricant Classify tablets that are prepared by compressing granular materials that have the capacity to release gas when in contact with water A. Buccal tablets B. Effervescent tablets C. Enteric-coated tablets D. Multiple-compressed tablets Opacifying agent used in the preparation of hard gelatin capsules A. Zinc oxide B. Titanium dioxide C. Sulfur dioxide D. Silicon dioxide Evaluate which statements are correct regarding hard and soft gelatin capsules. I. Aside from gelatin, two-piece capsules may also be prepared from HPMC and starches. (Vegetable capsules) II. If stored in an environment of high humidity, hard gelatin capsules may become distorted and lose their rigid shape. III. Soft gelatin capsules are made of gelatin to which glycerin or sorbitol has been added. IV. Soft gelatin capsules are used to encapsulate and hermetically seal non-aqueous liquids. A. I, III B. II, IV C. I, III, IV D. I, II, III, IV Analyze which drug delivery system achieves slow release of drug over an extended period of time. A. Site-specific release B. Delayed release C. Receptor release D. Sustained release Select the delivery system, which does NOT produce or maintain uniform drug blood levels within the therapeutic range but is more effective for patient compliance than conventional dosage forms. A. Site-specific release B. Receptor release C. Sustained release D. Delayed release Evaluate which statement is correct regarding rectal administration of drugs. A. The primary advantage of using rectal route is that it completely avoids the first-pass effect. B. The downside of rectal administration includes the stigma of violating the patient's dignity. C. Adult rectal suppositories weigh about 5 g when cocoa butter is employed as the base. D. Rectal suppositories for use by infants and children are about twice the weight and size of the adult suppositories. Determine which is NOT a good characteristic of a suppository base. A. Compatible with a variety of drugs B. Remains stable in rectal fluids C. Stable on storage D. Nontoxic and nonirritating to the mucous membranes Find the incorrect statement about Theobroma Oil. A. It is a naturally occurring alkaloid. B. The alpha form is metastable with a melting point below 30 °C. C. The beta crystal is its stable form with a melting point approaching 35 °C. D. It requires a fusion temperature of 40-50 °C to prevent a change in crystal form and melting point. Find the incorrect statement about Oleaginous Ointment Bases/ Hydrocarbon bases. A. They include fixed oils of vegetable origin, fats from animals and semisolid HC obtained from petroleum. B. Oleaginous ointment bases are excellent emollients. C. Vegetable oils and animal fats have a lower water absorbing capacity. D. Vegetable oils raise the melting point of ointments. Which of the following are used as ointment bases? I. Lanolin II. Mineral oil/ Liquid petrolatum III. Petrolatum IV. Glycerin V. Coconut oil A. I, II B. II. V C. I, III D. III, IV Classify White Petrolatum as an ointment base. A. Hydrocarbon base B. Absorption base C. Emulsion base (o/w type) D. Emulsion base (w/o type) Classify Anhydrous Lanolin as an ointment base. A. Emulsion base (o/w type) B. Emulsion base (w/o type) C. Absorption base D. Water-soluble base Classify Olive Oil as an ointment base. A. Absorption bases B. Vegetable oil bases C. Hydrocarbon bases D. Emulsifying bases Classify Polyethylene Glycol as an ointment base. A. Hydrocarbon bases B. Emulsifying bases C. Water absorbable bases D. Absorption bases Classify pectin paste, tragacanth jelly, bentonite gel, and colloidal magnesium aluminum silicate gels as semisolid base. A. Emulsifiable base B. Emulsified base C. Hydrogel D. Organogel Classify aluminum stearate, mineral oil gel, and theobroma oil as semisolid base. A. Emulsifiable base B. Organogel C. Emulsified base D. Hydrogel Classify hydrophilic petrolatum, wool fat, and anhydrous Tween base as semisolid base. A. Organogel B. Hydrogel C. Emulsified base D. Emulsifiable base Identify the components of White Ointment. A. White wax, beeswax B. White wax, spermaceti C. White wax, jojoba oil D. White wax, white petrolatum Identify the pharmaceutical ingredient that prevents drying of preparations due to its ability to retain moisture. A. Surfactant B. Humectant C. Binder D. Levigating agent The following are advantages of transdermal drug delivery systems, EXCEPT A. NOT suitable for all drugs B. avoid the risks and inconvenience of parenteral therapy C. avoid the first-pass effect D. provides the capacity for multiday therapy with a single application, thereby improving patient compliance A transdermal drug delivery system (TDDS) may be constructed of a number of layers. Determine the role of the drug reservoir or matrix system in a TDDS. A. Stores and releases the drug at the skin site B. Removed before application to enable drug release C. Maintains contact with the skin after application D. Protects the system from environmental entry and from loss of drug from the system or moisture from the skin Select the transdermal patch placed on scrotum in treatment of male hormone deficiency A. Estradiol (Climara®) B. Testosterone (Androderm®) C. Testosterone (Testoderm®) D. Nicotine (Nicoderm®) Select the transdermal patch applied weekly to the trunk, including abdomen and buttocks (alternating sites) A. Scopolamine (Transderm Scop®) B. Fentanyl (Duragesic®) C. Clonidine (Catapres-TTS®) D. Estradiol (Climara®) Which of the following terms is used to describe the solubility of a substance if 800 mg of the solute can be dissolved in 95 mL of water A. Slightly soluble B. Soluble C. Sparingly soluble D. Practically insoluble Which kind of water is purified by distillation or by reverse osmosis; contains no added substances; and intended for use as a solvent for the preparation of parenteral solutions. A. Water for Injection B. Sterile Water for Injection C. Purified Water D. Bacteriostatic Water for Injection Which kind of water is obtained by distillation, ionexchange treatment, reverse osmosis, or any other suitable process; contains no added substance; and NOT used in preparations intended for parenteral administration A. Sterile Water for Injection B. Purified Water C. Water for Injection D. Bacteriostatic Water for Injection Evaluate and select the correct statement for oral solutions. A. Oral solutions are conveniently administered in volumes of 10 mL (1 tbsp) or 4 mL (1 tsp) B. Oral pharmaceutical solutions are usually formulated so that the patient receives the usual dose in a conveniently administered volume, such as 5 mL (1 tsp), 10 mL, or 15 mL (1 tbsp) C. Oral rehydration solutions are given to patients with severe volume depletion of 20-30% of body weight D. Prednisolone sodium phosphate is a pharmaceutical oral emulsion There are three (3) groups of diluting agents based on their physical properties: aqueous diluting agents, hydroalcoholic diluting agents, and alcoholic diluting agents. Select the pair that is correctly matched. A. Peppermint Water - Aqueous B. Simple Syrup - Alcoholic C. Orange Flower Water - Hydroalcoholic D. Compound Cardamom Tincture - Aqueous Select the statements that best describe diluting agents for injections. I. Diluting agents for injections may be aqueous or nonaqueous. II. Aqueous diluting agents include such preparations as Sterile Water for Injection, Propylene Glycol and Dextrose. III. Nonaqueous diluting agents include fatty oils of vegetable origin and fatty esters. IV. Nonaqueous diluting agents are used to dissolve or dilute water soluble substances. V. Aqueous diluting agents are used to suspend water-soluble substances when it is desired to decrease the rate of absorption and prolong the duration of action of the drug substances. A. I, III B. II, IV, V C. IV, V D. I, II Select the statements that best describe syrups as diluting agents. I. Syrups are useful as diluting agents for water-insoluble drugs. II. Syrups act both as solvents and flavoring agents. III. Glycyrrhiza Syrup is an excellent vehicle for saline substances because of its colloidal properties, sweet flavor and licorice taste. IV. Aromatic Eriodictyon Syrup is the diluting agent of choice for masking the taste of urea. A. II, IV B. II, III C. I, III, IV D. I, II, III Select the oral dosage form which is prepared to be administered in small quantities with the help of a suitable measuring device. A. Linctus B. Elixir C. Oral emulsion D. Oral drop Select the oral dosage form which is a clear, flavored oral liquid containing one or more active ingredients dissolved in a suitable base that contains a high proportion of sucrose and may also contain ethanol (95%) or a diluted ethanol. A. Elixir B. Syrup C. Linctus D. Oral solution Select the oral dosage form which is a viscous oral liquid that contains one or more active ingredients in solution, the base generally containing large amounts of sucrose or sweetening agents; it may contain 95% ethanol as a preservative or as a solvent for flavors. A. Syrup B. Linctus C. Elixir D. Oral emulsion Select the oral dosage form that contains one or more active ingredients that are dissolved in a suitable base. A. Linctus B. Oral emulsion C. Elixir D. Oral solution Select the oral dosage form which contains one or more active ingredients that are unstable in the water phase but stabilized in oil in-water dispersions; either or both phases may contain dissolved solids. A. Oral drops B. Elixir C. Syrup D. Oral emulsion PROBLEM SOLVING: Calculate the volume of alcohol to be added to preserve the prescription below. Rx Active drug 5 mL Other Drug solids 3 mL Glycerin 15 mL Sucrose 25g Ethanol 95% q.s. Purified water, q.s. 100 mL A. 6.55 mL B. 6.50 mL C. 6.35 mL D. 6.21 mL Select the category of emulsifiers or stabilizers that are used primarily as thickening agents and stabilizers for oil-in-water emulsions of certain lotions and ointments for external use. A. Protein substances B. High molecular weight alcohols C. Finely divided solids D. Wetting agents Select the category of emulsifiers or stabilizers that are adsorbed at the interface between 2 immiscible liquid phases and form what amounts to a film of particles around the dispersed globules of o/w emulsions. A. Carbohydrate materials B. Wetting agents C. Finely divided solids D. High molecular weight alcohols Classify Glyceryl Monostearate as emulsifying agent. A. Protein substances B. High-molecular weight alcohols C. Finely divided solids D. Carbohydrate materials Classify Gelatin as emulsifying agent. A. Protein substances B. Carbohydrate materials C. Finely divided solids D. High-molecular weight alcohols Identify the pharmaceutical dispersed system that is a low-viscosity liquid preparation intended for application to the skin. A. Emulsion B. Gel C. Lotion D. Suspension Find the statement that is correct about suspensions. A. Suspensions are chemically more stable than solutions B. Suspensions do not ensure uniformity of dosage C. A highly viscous suspension provides ease of pouring D. Colloid mills or homogenizers are used for dry milling purposes prior to suspension Determine which is NOT a desirable characteristic of the disperse phase of a suspension. A. Dispersed phase is chemically and physically stable B. Dispersed particles are uniformly distributed throughout the dispersion medium [Show More]

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