ASCP (MB) Exam (Complete Solution) Graded A+

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ASCP (MB) Exam (Complete Solution) Graded A+ BCR-ABL ✔✔ Genes involved in cancer caused by t(9;22) CML ✔✔ Cancer caused by t(9:22) EWS-FLI1 ✔✔ Genes involved in cancer caused by t... (11;22) Ewing sarcoma ✔✔ Cancer caused by translocations involving 22q12 HER2(ERBB2) - 17q21.1 ✔✔ Receptor tyrosine kinase commonly overexpressed in breast cancer IHC, rtPCR, FISH ✔✔ Methods used to assess overexpression of common oncogenes KRAS ✔✔ Most common oncogene in human cancer, which activates MAPK pathway t(11,22)(q24,q12) ✔✔ Most common translocation in 85% of Ewing's sarcoma Synovial sarcoma ✔✔ 80% of this type of cancer is caused by t(X;18) FKHR (FOXO1A) ✔✔ Gene on chromosome 13 that is involved in translocations in rhabdomyosarcoma TP53 ✔✔ Inherited mutations in this gene cause Li-Fraumeni syndrome ATM ✔✔ Gene mutated in Ataxia Telangiectasia BRCA1 ✔✔ Mutations in this gene increase lifetime risk of developing breast or ovarian cancer to 60-80% RET ✔✔ Point mutations in this gene cause multiple endocrine neoplasia RET ✔✔ Translocations involving this gene commonly cause papillary carcinoma VHL ✔✔ Alterations in this gene lead to a syndrome, which predisposes to renal cell carcinoma Colon cancer ✔✔ This type of cancer is associated with a defective mismatch repair system (MMR) Hereditary nonpolyposis colorectal cancer (HNPCC) aka Lynch syndrome ✔✔ MSI is often associated (90%) with this type of inherited cancer [Show More]

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