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BIOM 500 Quiz 2 test solution docs 2020 with Graded answers

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BIOM 500 Quiz 2 test solution docs 2020 with Graded answers • Question 1 2 out of 2 points The major components of DNA repair mechanism does not include this; • Question 2 2 ou... t of 2 points Which of these protein/function combinations in the DNA repair regulation pathways is not correct? • Question 3 2 out of 2 points In a patient diagnosed with a Squamous cell carcinoma that exhibits high Base Excision Repair activity, you can predict that the tumor will be very sensitive to PARP1 Inhibitors. • Question 4 2 out of 2 points Which of these pairs of clinical applications of DNA repair mechanisms is not accurate? • Question 5 2 out of 2 points A transcriptionally active chromatin is described as a "closed chromatin". • Question 6 2 out of 2 points The amino acid that is most significant in the posttranslational modification of histones is___________? • Question 7 2 out of 2 points The role of epigenetics in cancer describes the non-heritable changes in gene expression in somatic cells that do not arise from alterations to primary base sequence of DNA. • Question 8 2 out of 2 points The Mismatch Repair mechanism of DNA repair employs MSH2, MLH1 and PMS2 in removing DNA adducts from the genome of affected cells. • Question 9 2 out of 2 points Which of these events do you think is likely to promote tumorigenesis in affected cells? • Question 10 0 out of 2 points A deficiency of ATM in the DNA damage response results in Radiosensitive DNA synthesis. • Question 11 2 out of 2 points You are studying tumor cells excised from a patient with suspected Colorectal cancer and you will like to evaluate the status of the DNA repair mechanisms in the tissues. Which of these will be helpful in estimating the functional status of the DNA repair mechanisms in this tissue? • Question 12 0 out of 2 points DNA methylation at CpG dinucleotides is a mechanism of epigenetic regulation of gene expression and is mediated by this enzyme; • Question 13 2 out of 2 points Cancer cells are generally characterized by genomic and chromosomal stability with an efficient DNA repair network. • Question 14 2 out of 2 points In evaluating the integrity of a cancer cells genomic DNA, which of these is least likely to result in DNA damage? • Question 15 2 out of 2 points Which of the mechanisms of DNA repair is very active in the genome of immune cells and produces a diversity of T-cell receptors and Immunoglobulins? • Question 16 2 out of 2 points The tumor suppressor gene p16 is frequently methylated on in Breast cancer cells. • Question 17 2 out of 2 points Which of these diseases is incorrectly paired with the corresponding defect in DNA repair? • Question 18 2 out of 2 points Malignant cells may be characterized by these except; • Question 19 2 out of 2 points The basic molecular unit of DNA packaging is describe as _____________? • Question 20 2 out of 2 points Which of these is a mechanism of DNA damage that can result in oncogenesis? [Show More]

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