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Basic Pharmacokinetics, PHAR 742

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1. The onset time for a drug given orally is the time for the a) Drug to reach the peak plasma drug concentration b) Drug to reach the minimum effective concentration (MEC) c) Drug to reach minimum... toxic concentration (MTC) d) Drug to begin to be eliminated from the body e) Drug to begin to be absorbed from the small intestine 2. Elimination of a drug is the ___________________________________ a) Process by which unchanged drug proceeds from the site of administration to the site of measurement b) Reversible transfer of a drug to and from the site of measurement within the body c) Irreversible loss of drug from the site of measurement d) Distribution and protein binding in the body e) Non-enzymatic hydrolysis of the drug in intestine 3. Which of the following statements is correct for measurement of drug concentration? a) Drug in feces reflects only the unabsorbed drug after oral dose b) Both urine and feces are important in mass balance study c) Drug concentration measured in saliva can not be used for therapeutic drug monitoring d) Plasma is obtained by allowing blood to clot, and then centrifuging to remove cells & some proteins e) Chromatographic methods for drug analysis are less discriminating since they cannot separate the drug from the interfering materials [Show More]

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