Principles of TDM, Common Drugs of Abuse, Toxicologic Agents, and the Physiology of Trace Elements. 20QnA Plus Explanations.

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Principles of TDM, Common Drugs of Abuse, Toxicologic Agents, and the Physiology of Trace Elements 1. Define the first pass effect 1. Drugs administered sublingually will pass through the liver... 2. Drugs administered intravenously must pass through the liver 3. Reduced activity on the first pass 4. Metabolism in the liver 2. I want to assess if a drug is working on my patient. I will then order a trough concentration of the drug. How many doses does it take for a person to reach the steady state of drug concentration? 1. 2 2. 15 3. 5 4. 7.5 3. Describe the two reactions which CYP450 enzymes perform to detoxify our blood 1. Phase 1 2. Fatty acid oxidation 3. Phase 2 4. Phase 3 4. What drug can cause ototoxicity, Nephrotoxicity, Red Man Syndrome 1. Phenytoin 2. Warfarin 3. Vancomycin 4. Aminoglycosides 5. What trace element causes cancers of the skin, lung, and bladder, and causes renal failure? 1. Manganese 2. Iron 3. Arsenic 4. Mercury 6. What trace element causes hemosiderosis or pediatric death 1. Zinc 2. Iron 3. Manganese 4. Copper 7. What drug can cause nystagmus, ataxia, slurred speech, seizures, coma 1. Warfarin 2. Cyclosporin A 3. Phenytoin 4. Lithium 8. What is the principle that discusses how widely spread the drug is in your body? 1. Absorption 2. Metabolism 3. Distribution 4. Excretion 9. What antibiotic can cause neurotoxicity, ototoxicity, and renal function impairment? 1. Cyclosporin A 2. Vancomycin 3. Phenytoin 4. 10. What trace element can cause nausea, vomiting, diarrhea, hepatic failure, tremor, hemolytic anemia, renal dysfunction, mental deterioration 1. Copper 2. Nickel 3. Mercury 4. Arsenic 11. What trace element can cause gastroenteritis, renal tubular dysfunction, dementia 1. Zinc 2. Arsenic 3. Mercury 4. Copper 12. What trace element can cause respiratory distress, pulmonary fibrosis 1. Arsenic 2. Zinc 3. Manganese 4. Nickel 13. What trace element can cause Dermatitis 1. Zinc 2. Iron 3. Nickel 4. Mercury 14. What is the most common cause of treatment failure? 1. Wrong drug perscribed 2. Rapid metabolism 3. Medication failure 4. Patient noncompliance 15. What drug can cause seizures, hypopnea, dysrhythmias, anemia 1. Digoxin 2. Lithium 3. Aminoglycosides 4. Vancomycin 16. What drug can cause palpitations, nausea, vomiting, drowsiness 1. Phenytoin 2. Cyclosporin A 3. Lithium 4. Digoxin 17. Your patient has severe alcoholic fatty liver disease and has a decreased albumin. What complications would you expect if the physician prescribed a medication at the same dose for the general population? 1. Increase the rate of Excretion 2. Decrease the Volume of Distribution 3. Overdosing 4. Underdosing 18. What drug can cause bleeding 1. Vancomycin 2. Warfarin 3. Digoxin 4. Aminoglycosides 19. What trace element can cause neurotoxicity and Parkinson-like symptoms? 1. Nickel 2. Iron 3. Manganese 4. Copper 20. How is the Therapeutic Window defined? 1. Above the Minimum Effective Concentration for the desired response 2. Below the Minimum Effective Concentration for the adverse response 3. Below the Minimum Effective Concentration for the adverse response 4. Above the Minimum Effective Concentration for the desired response [Show More]

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